A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction
نویسندگان
چکیده
منابع مشابه
A Genetic Risk Score Combining Ten Psoriasis Risk Loci Improves Disease Prediction
Psoriasis is a chronic, immune-mediated skin disease affecting 2-3% of Caucasians. Recent genetic association studies have identified multiple psoriasis risk loci; however, most of these loci contribute only modestly to disease risk. In this study, we investigated whether a genetic risk score (GRS) combining multiple loci could improve psoriasis prediction. Two approaches were used: a simple ri...
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More than 30 independent single-nucleotide polymorphisms (SNPs) have been associated with Alzheimer's disease (AD) risk by genome-wide association studies (GWAS) in European. We aimed to confirm these SNPs in Chinese Han and investigate the utility of these genetic markers. We randomly divided 459 sporadic AD (SAD) patients and 751 cognitively normal controls into two sets (discovery and testin...
متن کاملPrediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities Study.
Recent studies have evaluated whether incorporating nontraditional risk factors improves coronary heart disease (CHD) prediction models. This 1986-2001 US study aggregated the contribution of multiple single nucleotide polymorphisms into a genetic risk score (GRS) and assessed whether the GRS plus traditional risk factors predict CHD better than traditional risk factors alone. The Atheroscleros...
متن کاملOriginal Contribution Prediction of Coronary Heart Disease Risk using a Genetic Risk Score: The Atherosclerosis Risk in Communities Study
1 Human Genetics Center and Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX. 2 Celera, Alameda, CA. 3 Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, NC. 4 Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH. 5 Cardiovascular Research Institute, University of California, San Franc...
متن کاملThe association between 38 previously reported polymorphisms and psoriasis in a Polish population: High predicative accuracy of a genetic risk score combining 16 loci
OBJECTIVES To confirm the association of previously discovered psoriasis (Ps) risk loci with the disease in a Polish population and to create predictive models based on the combination of these single nucleotide polymorphisms (SNPs). MATERIAL AND METHODS Thirty-eight SNPs were genotyped in 480 Ps patients and 490 controls. Alleles distributions were compared between patients and controls, as ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0019454